Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03EFD
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| Former ID |
DIB011163
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| Drug Name |
KT-95
|
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| Synonyms |
KT-90
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| Indication | Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51] | Terminated | [1] | ||
| Company |
Toho Chemical Industry Co
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
[C@]123c4c5O[C@H]1[C@H](SC(=O)C)CC[C@H]2[C@H](N(CC1CC1)<br />CC3)Cc4ccc5OC(=O)C
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| Target and Pathway | |||||
| Target(s) | Kappa-type opioid receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Opioid prodynorphin pathway | |||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007966) | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 318). | ||||
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