Drug General Information
Drug ID
D03EDQ
Former ID
DNAP001262
Drug Name
Vismodegib
Synonyms
Erivedge (TN); Vismodegib (SHH inhibitor)
Drug Type
Small molecular drug
Indication Metastatic or locally advanced basal cell carcinoma [ICD9: 173; ICD10:C44] Approved [532210], [542006]
Company
Genentech
Structure
Download
2D MOL

3D MOL

Formula
C19H14Cl2N2O3S
InChI
InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)
InChIKey
BPQMGSKTAYIVFO-UHFFFAOYSA-N
CAS Number
CAS 879085-55-9
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:66903
SuperDrug ATC ID
L01XX43
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) smoothened receptor Target Info Modulator [532210]
KEGG Pathway Hedgehog signaling pathway
Pathways in cancer
Proteoglycans in cancer
Basal cell carcinoma
PANTHER Pathway Hedgehog signaling pathway
Pathway Interaction Database Signaling events mediated by the Hedgehog family
Hedgehog signaling events mediated by Gli proteins
Reactome Class B/2 (Secretin family receptors)
Hedgehog 'off' state
Activation of SMO
WikiPathways Hedgehog Signaling Pathway
Hair Follicle Development: Organogenesis (Part 2 of 3)
Hair Follicle Development: Induction (Part 1 of 3)
Integrated Pancreatic Cancer Pathway
GPCR ligand binding
GPCRs, Other
References
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
Ref 542006(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6975).
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.

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