Drug General Information
Drug ID
D03DLZ
Former ID
DNC013655
Drug Name
2-(1H-indol-3-yl)-N,N-dimethylethanamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529336]
Structure
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2D MOL

3D MOL

Formula
C12H16N2
Canonical SMILES
CN(C)CCC1=CNC2=CC=CC=C21
InChI
1S/C12H16N2/c1-14(2)8-7-10-9-13-12-6-4-3-5-11(10)12/h3-6,9,13H,7-8H2,1-2H3/i1-1
InChIKey
DMULVCHRPCFFGV-BJUDXGSMSA-N
PubChem Compound ID
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Inhibitor [529336]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 529336Bioorg Med Chem. 2008 Apr 15;16(8):4661-9. Epub 2008 Feb 14.The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands.
Ref 529336Bioorg Med Chem. 2008 Apr 15;16(8):4661-9. Epub 2008 Feb 14.The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands.

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