| Drug General Information |
| Drug ID |
D03CRT
|
| Former ID |
DIB019193
|
| Drug Name |
compound 10
|
| Synonyms |
Aurora A inhibitor I; 2,4-Bisanilinopyrimidine, 10
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Formula |
C31H31ClFN7O2
|
| InChI |
InChI=1S/C31H31ClFN7O2/c1-2-39-15-17-40(18-16-39)28(41)19-21-7-11-24(12-8-21)36-31-34-20-26(33)29(38-31)35-23-13-9-22(10-14-23)30(42)37-27-6-4-3-5-25(27)32/h3-14,20H,2,15-19H2,1H3,(H,37,42)(H2,34,35,36,38)
|
| InChIKey |
AKSIZPIFQAYJGF-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
85095615, 85240463, 89933648, 99437157, 103596589, 124757258, 125164062, 125748895, 131480877, 135686178, 135686179, 135686200, 135686201, 136348808, 136367424, 136368081, 144115645, 152134488, 152258891, 160647739, 160826427, 162037605, 162202567, 162777849, 163387978, 174006379, 177748916, 180371647, 185975398, 188899551, 202817920, 204366346, 223655647, 223705107, 240403279, 242060194, 252110023, 252158748, 252160286, 252166676, 252214912
|
| Target and Pathway |
| Target(s) |
mRNA of Aurora B |
Target Info |
Inhibitor |
[1]
|
|---|
| Aurora protein kinase |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Oocyte meiosis
|
|
Pathway Interaction Database
|
Aurora B signaling
|
|
Signaling by Aurora kinases
|
|
Aurora C signaling
|
|
FOXM1 transcription factor network
|
|
Aurora A signaling
|
|
Reactome
|
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
|
|
Separation of Sister Chromatids
|
|
Resolution of Sister Chromatid Cohesion
|
|
RHO GTPases Activate Formins
|
|
Mitotic PrometaphaseR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
|
|
WikiPathways
|
Mitotic Metaphase and Anaphase
|
|
Mitotic Prometaphase
|
|
Regulation of Microtubule Cytoskeleton
|
|
miR-targeted genes in lymphocytes - TarBase
|
|
miR-targeted genes in epithelium - TarBase
|
|
APC/C-mediated degradation of cell cycle proteinsWP437:EGF/EGFR Signaling Pathway
|
|
JAK/STAT
|
|
Gastric Cancer Network 1
|
|
Integrated Breast Cancer Pathway
|
|
APC/C-mediated degradation of cell cycle proteins
|
| References |
| REF 1 | A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J Med Chem. 2009 May 28;52(10):3300-7. |
|---|
