| Drug General Information |
| Drug ID |
D03ABH
|
| Former ID |
DIB006118
|
| Drug Name |
Deriglidole
|
| Synonyms |
SL-84.0418; SL-84.0714; SL-84.0715
|
| Drug Type |
Small molecular drug
|
| Indication |
Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1]
|
Discontinued in Phase 2 |
[1]
|
|---|
| Company |
Synthelabo
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H21N3
|
| Canonical SMILES |
N12C(C3=NCCN3)(Cc3c1c(CC2)ccc3)CCC
|
| CAS Number |
CAS 122830-14-2
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Alpha-2C adrenergic receptor |
Target Info |
Modulator |
[2]
|
|---|
| Alpha-1D adrenergic receptor |
Target Info |
Modulator |
[2]
|
|
KEGG Pathway
|
cGMP-PKG signaling pathway
|
|
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Adrenergic signaling in cardiomyocytes
|
|
Vascular smooth muscle contraction
|
|
Salivary secretion
|
|
NetPath Pathway
|
IL2 Signaling Pathway
|
|
PANTHER Pathway
|
Alpha adrenergic receptor signaling pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Reactome
|
Adrenoceptors
|
|
Adrenaline signalling through Alpha-2 adrenergic receptor
|
|
Adrenaline,noradrenaline inhibits insulin secretion
|
|
G alpha (i) signalling events
|
|
G alpha (z) signalling events
|
|
Surfactant metabolismR-HSA-390696:Adrenoceptors
|
|
G alpha (q) signalling events
|
|
G alpha (12/13) signalling events
|
|
WikiPathways
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
Platelet Aggregation (Plug Formation)
|
|
Integration of energy metabolism
|
|
GPCR ligand binding
|
|
GPCR downstream signalingWP58:Monoamine GPCRs
|
|
Calcium Regulation in the Cardiac Cell
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
GPCR downstream signaling
|
|
GPCRs, Other
|
| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000010) |
|---|
| REF 2 | Mechanisms of the hypoglycemic effects of the alpha2-adrenoceptor antagonists SL84.0418 and deriglidole. Life Sci. 1998;62(9):839-52. |
|---|
