Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02YYF
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| Former ID |
DAP000939
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| Drug Name |
Bretylium
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| Synonyms |
Bretylum; Bretylium tolsylate; Bretylium tosylate(USAN); N-(2-bromobenzyl)-N,N-dimethylethanaminium; N-ethyl-N,N-dimethyl-2-bromobenzenemethanaminium; Benzenemethanaminium, 2-bromo-N-ethyl-N,N-dimethyl-, salt with 4-methylbenzenesulfonic acid (1:1); (2-bromobenzyl)ethyldimethylaminium; (2-bromophenyl)methyl-ethyl-dimethylazanium; (o-Bromobenzyl)ethyldimethylammonium p-toluenesulfonate; 2-bromo-N-ethyl-N,N-dimethylbenzenemethanaminium
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| Drug Type |
Small molecular drug
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| Indication | Ventricular fibrillation [ICD10:I49.01] | Approved | [1] | ||
| Therapeutic Class |
Antiarrhythmic Agents
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| Company |
Hospira Inc
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| Structure |
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Download2D MOL |
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| Formula |
C11H17BrN+
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| InChI |
InChI=1S/C11H17BrN/c1-4-13(2,3)9-10-7-5-6-8-11(10)12/h5-8H,4,9H2,1-3H3/q+1
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| InChIKey |
AAQOQKQBGPPFNS-UHFFFAOYSA-N
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| CAS Number |
CAS 59-41-6
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| PubChem Compound ID | |||||
| PubChem Substance ID |
9073, 794516, 5580995, 7978814, 8151623, 11468090, 11486799, 14749639, 29221595, 46505320, 47365410, 47515523, 47515524, 48035343, 49699004, 50064953, 50113154, 50113155, 50310316, 57321311, 85209526, 92740966, 104300566, 126407358, 126729469, 127378478, 131273742, 134222665, 134338214, 135021960, 137001461, 142246611, 160964492, 162201420, 175267511, 178103706, 179225252, 223454297, 223518984, 223814627, 225144298, 226405825, 246089195
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| SuperDrug ATC ID |
C01BD02
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| SuperDrug CAS ID |
cas=000061756
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| Target and Pathway | |||||
| Target(s) | Beta-1 adrenergic receptor | Target Info | Antagonist | [2], [3] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cGMP-PKG signaling pathway | |||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Endocytosis | |||||
| Adrenergic signaling in cardiomyocytes | |||||
| Gap junction | |||||
| Salivary secretion | |||||
| Dilated cardiomyopathy | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Beta1 adrenergic receptor signaling pathway | |||||
| PathWhiz Pathway | Muscle/Heart Contraction | ||||
| Reactome | Adrenoceptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| Calcium Regulation in the Cardiac Cell | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Endothelin Pathways | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
| REF 2 | Dissociation of autonomic controls of heart rate in weaning-aged borderline hypertensive rats by perinatal NaCl. J Auton Nerv Syst. 1990 Mar;29(3):219-26. | ||||
| REF 3 | Components of functional sympathetic control of heart rate in neonatal rats. Am J Physiol. 1985 May;248(5 Pt 2):R601-10. | ||||
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