Drug Information

Drug General Information
Drug ID
D02WBY
Former ID
DIB020112
Drug Name
JNJ-5207787
Synonyms
JNJ5207787
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540444]
Structure
Download
2D MOL
Formula
C32H38N4O2
InChI
InChI=1S/C32H38N4O2/c1-24(37)35-20-14-28-10-11-30(22-31(28)35)36(32(38)12-9-26-7-4-8-27(21-26)23-33)29-15-18-34(19-16-29)17-13-25-5-2-3-6-25/h4,7-12,21-22,25,29H,2-3,5-6,13-20H2,1H3/b12-9+
InChIKey
DSEJCLDJIFTPPH-FMIVXFBMSA-N
PubChem Compound ID
10324083
PubChem Substance ID
15333596, 22693389, 41389900, 49684240, 53788161, 75921783, 103188428, 104030086, 141399908, 144116092, 172113504, 178100491, 196375756, 198951924, 230728955, 230728968, 241376764, 249618054, 252109991, 252157716
Target and Pathway
Target(s) Neuropeptide Y receptor type 2 Target Info Antagonist [526883]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 540444(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3504).
Ref 526883Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor. J Pharmacol Exp Ther. 2004 Mar;308(3):1130-7. Epub 2003 Nov 14.

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