Drug General Information
Drug ID
D02VNJ
Former ID
DIB009654
Drug Name
CRTH2 antagonists
Synonyms
CRTH2 antagonists (allergic asthma/allergic rhinitis/inflammatory disease); CRTH2 antagonists (allergic asthma/allergic rhinitis/inflammatory disease), Abbott
Indication Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4] Investigative [552092]
Company
Abbott Laboratories
Structure
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2D MOL

3D MOL

Canonical SMILES
C(=O)(Cc1c2c(n(c1C)S(=O)(=O)c1ccc(cc1)S(=O)(=O)C)scc2)O
Target and Pathway
Target(s) Putative G-protein coupled receptor 44 Target Info Antagonist [543776]
Reactome Prostanoid ligand receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 552092Thienopyrrole acetic acids as antagonists of the CRTH2 receptor. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1861-4
Ref 543776(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 339).

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