Drug General Information
Drug ID
D02UKE
Former ID
DNC014388
Drug Name
5-(pyridin-4-yl)-1,3,4-thiadiazole-2(3H)-thione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530900]
Structure
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2D MOL

3D MOL

Formula
C7H5N3S2
Canonical SMILES
C1=CN=CC=C1C2=NNC(=S)S2
InChI
1S/C7H5N3S2/c11-7-10-9-6(12-7)5-1-3-8-4-2-5/h1-4H,(H,10,11)
InChIKey
BSPHQWQMWIUIPM-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Tyrosine oxidase Target Info Inhibitor [530900]
BioCyc Pathway (S)-reticuline biosynthesis
Eumelanin biosynthesis
L-dopachrome biosynthesis
KEGG Pathway Tyrosine metabolism
Riboflavin metabolism
Metabolic pathways
Melanogenesis
PathWhiz Pathway Riboflavin Metabolism
Tyrosine Metabolism
WikiPathways Dopamine metabolism
References
Ref 530900Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. Epub 2010 Apr 13.New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.
Ref 530900Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. Epub 2010 Apr 13.New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.

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