Drug General Information
Drug ID
D02RWC
Former ID
DIB019925
Drug Name
GNF-5837
Synonyms
GNF 5837; GNF5837
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532813]
Structure
Download
2D MOL
Formula
C28H21F4N5O2
InChI
InChI=1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30,31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14,33-34H,1H3,(H,36,38)(H2,35,37,39)/b21-12-
InChIKey
YYDUWLSETXNJJT-MTJSOVHGSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) BDNF/NT-3 growth factors receptor Target Info Inhibitor [532813]
Trk receptor Target Info Inhibitor [532813]
KEGG Pathway MAPK signaling pathway
Neurotrophin signaling pathway
Alcoholism
Pathway Interaction Database SHP2 signaling
Posttranslational regulation of adherens junction stability and dissassembly
Neurotrophic factor-mediated Trk receptor signaling
Reactome NGF-independant TRKA activationR-HSA-170984:ARMS-mediated activation
NGF-independant TRKA activation
PI3K/AKT activation
WikiPathways SIDS Susceptibility Pathways
BDNF signaling pathwayWP382:MAPK Signaling Pathway
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
NGF signalling via TRKA from the plasma membrane
References
Ref 532813Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models. ACS Med Chem Lett. 2012 Jan 1;3(2):140-5.
Ref 532813Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models. ACS Med Chem Lett. 2012 Jan 1;3(2):140-5.

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