Drug Information

Drug General Information
Drug ID
D02RTS
Former ID
DIB019149
Drug Name
citric acid
Synonyms
citrate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539603]
Structure
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2D MOL

3D MOL
Formula
C6H8O7
InChI
InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChIKey
KRKNYBCHXYNGOX-UHFFFAOYSA-N
PubChem Compound ID
311
PubChem Substance ID
3458, 89571, 493004, 583624, 583626, 583628, 583666, 583709, 583750, 583782, 583785, 583920, 583952, 583961, 583962, 583990, 584046, 584048, 584050, 584052, 584054, 584057, 584096, 584098, 584199, 584208, 584526, 584546, 584681, 584697, 584768, 584772, 585348, 585511, 585681, 585694, 587788, 607173, 819959, 820166, 820611, 820613, 820722, 820723, 820726, 820754, 820758, 820760, 820762, 820764
Target and Pathway
Target(s) Transient receptor potential cation channel subfamily V member 4 Target Info Activator [526597]
TRPP2 Target Info Activator [528357]
KEGG Pathway Inflammatory mediator regulation of TRP channels
Reactome TRP channels
References
Ref 539603(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2478).
Ref 526597Impaired pressure sensation in mice lacking TRPV4. J Biol Chem. 2003 Jun 20;278(25):22664-8. Epub 2003 Apr 13.
Ref 528357Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12569-74. Epub 2006 Aug 4.

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