Drug Information

Drug General Information
Drug ID
D02QUS
Former ID
DIB020845
Drug Name
RP-52770
Synonyms
RP 52770
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539147]
Structure
Download
2D MOL
Formula
C18H14ClN3OS
InChI
InChI=1S/C18H14ClN3OS/c19-13-4-1-5-14(9-13)21-17(23)15-6-8-22-16(15)11-24-18(22)12-3-2-7-20-10-12/h1-10,18H,11H2,(H,21,23)
InChIKey
MJGVBIXLFIUPQU-UHFFFAOYSA-N
PubChem Compound ID
146417
PubChem Substance ID
10249225, 15496970, 46223643, 57346373, 74725352, 85209774, 103253902, 103946018, 104413963, 126440670, 128603927, 135103755, 135649816, 135651127, 236244543
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Antagonist [533359]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 539147(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1839).
Ref 533359[3H]52770 RP, a platelet-activating factor receptor antagonist, and tritiated platelet-activating factor label a common specific binding site in human polymorphonuclear leukocytes. J Pharmacol Exp Ther. 1988 Feb;244(2):709-15.

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