Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02QLY
|
||||
| Former ID |
DNC009541
|
||||
| Drug Name |
2-Hydroxy-N,6-bis(3-hydroxyphenyl)-1-naphthamide
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C23H17NO4
|
||||
| Canonical SMILES |
C1=CC(=CC(=C1)O)C2=CC3=C(C=C2)C(=C(C=C3)O)C(=O)NC4=CC(=<br />CC=C4)O
|
||||
| InChI |
1S/C23H17NO4/c25-18-5-1-3-14(12-18)15-7-9-20-16(11-15)8-10-21(27)22(20)23(28)24-17-4-2-6-19(26)13-17/h1-13,25-27H,(H,24,28)
|
||||
| InChIKey |
JFOMBBOIWCMHKV-UHFFFAOYSA-N
|
||||
| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Estradiol 17 beta-dehydrogenase 1 | Target Info | Inhibitor | [1] | |
| BioCyc Pathway | Superpathway of steroid hormone biosynthesis | ||||
| Estradiol biosynthesis I | |||||
| KEGG Pathway | Steroid hormone biosynthesis | ||||
| Metabolic pathways | |||||
| Ovarian steroidogenesis | |||||
| NetPath Pathway | FSH Signaling Pathway | ||||
| PANTHER Pathway | Androgen/estrogene/progesterone biosynthesis | ||||
| PathWhiz Pathway | Androgen and Estrogen Metabolism | ||||
| Reactome | The canonical retinoid cycle in rods (twilight vision) | ||||
| WikiPathways | Steroid Biosynthesis | ||||
| Metabolism of steroid hormones and vitamin D | |||||
| Prostate Cancer | |||||
| References | |||||
| REF 1 | J Med Chem. 2008 Aug 14;51(15):4685-98. Epub 2008 Jul 17.Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design, synthesis, biological evaluation, and pharmacokinetics. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.