Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02PIN
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| Former ID |
DIB015880
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| Drug Name |
GR-94839
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| Drug Type |
Small molecular drug
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| Indication | Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] | Terminated | [1] | ||
| Company |
Glaxo Group Research Ltd
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| Structure |
|
Download2D MOL |
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| Formula |
C19H25Cl2N3O3
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| Canonical SMILES |
N1(C(CN(C(=O)C)CC1)CN1CC(CC1)O)C(=O)Cc1cc(c(cc1)Cl)Cl
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| CAS Number |
CAS 133407-20-2
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Kappa-type opioid receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Opioid prodynorphin pathway | |||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003733) | ||||
| REF 2 | GR94839, a kappa-opioid agonist with limited access to the central nervous system, has antinociceptive activity. Br J Pharmacol. 1992 Aug;106(4):783-9. | ||||
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