Drug General Information
Drug ID
D02OJC
Former ID
DCL000663
Drug Name
Xaliproden
Synonyms
Xaliproden (USAN); 1,2,3,6-tetrahydro-1-(2-(2-naphthalenyl)ethyl)-4-(3-(trifluoromethyl)phenyl)-pyridine; 1,2,3,6-tetrahydro-1-(2-(2-naphthyl)ethyl)-4-(alpha,alpha,alpha-trifluoro-m-tolyl)pyridine; 1-(2-(2-Naphthyl)ethyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine; 1-(2-naphthalen-2-ylethyl)-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-pyridine; 1-[2-(2-naphthyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine
Drug Type
Small molecular drug
Indication Alzheimer disease; Peripheral sensory neuropathies; Lateral sclerosis [ICD9: 331.0, 356.0, 356.8; ICD10:G30, G64, G90.0, G12.2] Discontinued in Phase 3 [544941]
Company
Sanofi-Aventis
Structure
Download
2D MOL

3D MOL

Formula
C24H22F3N
Canonical SMILES
C1CN(CC=C1C2=CC(=CC=C2)C(F)(F)F)CCC3=CC4=CC=CC=C4C=C3
InChI
1S/C24H22F3N/c25-24(26,27)23-7-3-6-22(17-23)20-11-14-28(15-12-20)13-10-18-8-9-19-4-1-2-5-21(19)16-18/h1-9,11,16-17H,10,12-15H2
InChIKey
WJJYZXPHLSLMGE-UHFFFAOYSA-N
CAS Number
CAS 428863-50-7
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
N07XX03
SuperDrug CAS ID
cas=135354028
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Antagonist [549823]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 544941Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001601)
Ref 549823Pharma & Vaccines. Product Development Pipeline. April 29 2009.

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