Drug Information

Drug General Information
Drug ID
D02NTS
Former ID
DIB000312
Drug Name
JNJ-39393406
Drug Type
Small molecular drug
Indication Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] Phase 1 [523838]
Company
Janssen Pharmaceutica NV
Structure
Download
2D MOL

3D MOL
Formula
C19H18F2N6O3
Canonical SMILES
CN(C)C(=O)CCN1C(=NC(=N1)NC2=CC3=C(C=C2)OC(O3)(F)F)C4=CC<br />=NC=C4
InChI
1S/C19H18F2N6O3/c1-26(2)16(28)7-10-27-17(12-5-8-22-9-6-12)24-18(25-27)23-13-3-4-14-15(11-13)30-19(20,21)29-14/h3-6,8-9,11H,7,10H2,1-2H3,(H,23,25)
InChIKey
IURMHZBQEYNQOH-UHFFFAOYSA-N
PubChem Compound ID
16755766
PubChem Substance ID
26744551, 54226415, 137917515, 172113562, 198979245, 227101842, 246936097
Target and Pathway
Target(s) Neuronal acetylcholine receptor protein, alpha-7 chain Target Info Modulator [531960]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Nicotine addiction
Chemical carcinogenesis
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Nicotinic acetylcholine receptor signaling pathway
Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
References
Ref 523838ClinicalTrials.gov (NCT01556217) A Pharmacokinetic Study to Characterize JNJ-39393406 in the Cerebrospinal Fluid of Healthy Volunteers. U.S. National Institutes of Health.
Ref 531960Allosteric alpha-7 nicotinic receptor modulation and P50 sensory gating in schizophrenia: a proof-of-mechanism study. Neuropharmacology. 2013 Jan;64:197-204.

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