Drug Information

Drug General Information
Drug ID
D02NLI
Former ID
DNC011835
Drug Name
PD-85639
Drug Type
Small molecular drug
Indication Discovery agent Terminated [545294]
Structure
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2D MOL

3D MOL
Formula
C24H32N2O
Canonical SMILES
CC1CCCC(N1CCCNC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)C
InChI
1S/C24H32N2O/c1-19-11-9-12-20(2)26(19)18-10-17-25-24(27)23(21-13-5-3-6-14-21)22-15-7-4-8-16-22/h3-8,13-16,19-20,23H,9-12,17-18H2,1-2H3,(H,25,27)
InChIKey
BPZBEIHSHWNWTE-UHFFFAOYSA-N
PubChem Compound ID
9950970
Target and Pathway
Target(s) Sodium channel Target Info Inhibitor [525961]
Voltage-gated sodium channel subunit alpha Nav1.3 Target Info Inhibitor [533974]
Sodium channel protein type 5 subunit alpha Target Info Inhibitor [525961]
KEGG Pathway Dopaminergic synapsehsa04261:Adrenergic signaling in cardiomyocytes
PathWhiz Pathway Muscle/Heart Contraction
Reactome Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and Ankyrins
WikiPathways SIDS Susceptibility Pathways
Cardiac Progenitor Differentiation
References
Ref 545294Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002730)
Ref 525961J Med Chem. 2001 Jan 18;44(2):115-37.Medicinal chemistry of neuronal voltage-gated sodium channel blockers.
Ref 533974J Med Chem. 1994 Jan 21;37(2):268-74.Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers.

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