Drug Information

Drug General Information
Drug ID
D02KOF
Former ID
DAP000653
Drug Name
Lomefloxacin
Synonyms
LFLX; Lomefloxacine; Lomefloxacino; Lomefloxacinum; Lomefloxacine [French]; Lomefloxacino [Spanish]; Lomefloxacinum[Latin]; SC 4711; SC 47111A; DM 10 (bactericide); DM-10; Lomefloxacin (USAN); Maxaquin (TN); Maxaquin (hydrochloride); Okacyn (TN); SC-4711; SC-47111A; Uniquin (TN); Lomefloxacin [USAN:BAN:INN]; NY-198 (hydrochloride); SC-47111 (hydrochloride); SC-47111B (mesylate); (+-)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1,4-Dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid; 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride
Drug Type
Small molecular drug
Indication Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] Approved [538536]
Therapeutic Class
Antibiotics
Company
Pharmacia Corp
Structure
Download
2D MOL

3D MOL
Formula
C17H19F2N3O3
Canonical SMILES
CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O
InChI
1S/C17H19F2N3O3/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25)
InChIKey
ZEKZLJVOYLTDKK-UHFFFAOYSA-N
CAS Number
CAS 98079-51-7
PubChem Compound ID
3948
PubChem Substance ID
9289, 602955, 5037068, 7849377, 7979788, 8152478, 11335540, 11360779, 11364325, 11366887, 11369449, 11372706, 11373775, 11377611, 11461751, 11466266, 11467386, 11484587, 11485972, 11488512, 11491309, 11491973, 11495245, 14851991, 24278514, 29223062, 46508499, 47291062, 47588922, 47588923, 47736397, 47736398, 48035031, 48110376, 48334411, 48334412, 49698401, 49835841, 50042514, 50111115, 50122921, 50122922, 50203310, 56313756, 57322062, 85321506, 85788434, 90340951, 92309292, 103178831
SuperDrug ATC ID
J01MA07; S01AE04
SuperDrug CAS ID
cas=098079517
Target and Pathway
Target(s) DNA topoisomerase II Target Info Inhibitor [535555]
References
Ref 538536FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 020013.
Ref 535555Inhibition of human topoisomerase IIalpha by fluoroquinolones and ultraviolet A irradiation. Toxicol Sci. 2002 Sep;69(1):16-22.

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