Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02JAY
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| Former ID |
DCL000237
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| Drug Name |
Stannsoporfin
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| Synonyms |
SNMPP; Stanate; Sn Mesoporphyrin; Tin mesoporphyrin; Stanate (TN); Stannsoporfin (USAN/INN)
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| Drug Type |
Small molecular drug
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| Indication | Neonatal hyperbilirubinemia; Jaundice [ICD9: 773, 774, 782.4; ICD10:P58, P59, R17] | Phase 2 | [524340] | ||
| Company |
InfaCare Pharma.
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| Structure |
|
Download2D MOL |
|||
| Formula |
C34H36Cl2N4O4Sn
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| Canonical SMILES |
[H+].[H+].CCC1=C(C2=NC1=CC3=C(C(=C([N-]3)C=C4C(=C(C(=CC<br />5=NC(=C2)C(=C5C)CC)[N-]4)C)CCC(=O)[O-])CCC(=O)[O-])C)C.<br />[Cl-].[Cl-].[Sn+4]
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| InChI |
1S/C34H38N4O4.2ClH.Sn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;;/h13-16H,7-12H2,1-6H3,(H4,35,36,37,38,39,40,41,42);2*1H;/q;;;+4/p-4
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| InChIKey |
LLDZJTIZVZFNCM-UHFFFAOYSA-J
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| CAS Number |
CAS 106344-20-1
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Heme oxygenase | Target Info | Inhibitor | [536043] | |
| BioCyc Pathway | Heme degradation | ||||
| Pathway Interaction Database | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | ||||
| HIF-1-alpha transcription factor network | |||||
| PathWhiz Pathway | Porphyrin Metabolism | ||||
| Reactome | Iron uptake and transport | ||||
| WikiPathways | Oxidative Stress | ||||
| Transcriptional activation by NRF2 | |||||
| NRF2 pathway | |||||
| Nuclear Receptors Meta-Pathway | |||||
| miR-targeted genes in squamous cell - TarBase | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| miR-targeted genes in leukocytes - TarBase | |||||
| miR-targeted genes in epithelium - TarBase | |||||
| References | |||||
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