Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02HWP
|
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| Former ID |
DNC011357
|
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| Drug Name |
CHLOROXINE
|
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| Drug Type |
Small molecular drug
|
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| Indication | Erythema [ICD9: 695; ICD10:L51-L54] | Approved | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C9H5Cl2NO
|
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| Canonical SMILES |
C1=CC2=C(C(=C(C=C2Cl)Cl)O)N=C1
|
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| InChI |
1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
|
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| InChIKey |
WDFKMLRRRCGAKS-UHFFFAOYSA-N
|
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| CAS Number |
CAS 773-76-2
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Kappa-type opioid receptor | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Opioid prodynorphin pathway | |||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
| REF 2 | Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). | ||||
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