| Drug General Information |
| Drug ID |
D02HNG
|
| Former ID |
DCL000567
|
| Drug Name |
MK-0752
|
| Drug Type |
Small molecular drug
|
| Indication |
Alzheimer disease [ICD9: 331; ICD10:G30]
|
Phase 2 |
[1]
|
|---|
| Company |
Merck
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C21H21ClF2O4S
|
| Canonical SMILES |
C1CC(CCC1CCC(=O)O)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C<br />=C3)Cl
|
| InChI |
1S/C21H21ClF2O4S/c22-15-2-5-17(6-3-15)29(27,28)21(18-13-16(23)4-7-19(18)24)11-9-14(10-12-21)1-8-20(25)26/h2-7,13-14H,1,8-12H2,(H,25,26)
|
| InChIKey |
XCGJIFAKUZNNOR-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
14759485, 26656969, 44839430, 76228635, 135293803, 136340317, 136349535, 136350005, 136367666, 137276028, 138981598, 144116224, 144116225, 152258282, 160647121, 162011365, 162038054, 162202770, 164033271, 164042765, 164193934, 174529467, 186022490, 223397844, 223701381, 223705128, 227040993, 227040994, 227040995, 241381736, 242559493, 242671661, 244152522, 245650540, 249492837, 249820123, 249860971, 250224828, 251963155, 252073854, 252109926, 252215813, 252437558, 252451651
|
| Target and Pathway |
| Target(s) |
Gamma-secretase |
Target Info |
Modulator |
[1]
|
|---|
|
KEGG Pathway
|
Notch signaling pathway
|
|
Alzheimer's disease
|
|
PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
|
Alzheimer disease-presenilin pathway
|
|
Notch signaling pathway
|
|
Pathway Interaction Database
|
Notch signaling pathway
|
|
Presenilin action in Notch and Wnt signaling
|
|
p75(NTR)-mediated signaling
|
|
Syndecan-3-mediated signaling events
|
|
Reactome
|
Nuclear signaling by ERBB4
|
|
Regulated proteolysis of p75NTR
|
|
NRIF signals cell death from the nucleus
|
|
Activated NOTCH1 Transmits Signal to the Nucleus
|
|
Constitutive Signaling by NOTCH1 PEST Domain Mutants
|
|
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
|
|
NOTCH2 Activation and Transmission of Signal to the Nucleus
|
|
EPH-ephrin mediated repulsion of cells
|
|
WikiPathways
|
Notch Signaling Pathway
|
|
Signaling by ERBB4
|
|
Signaling by NOTCH3
|
|
Signaling by NOTCH4
|
|
Signaling by NOTCH1
|
|
Signaling by NOTCH2
|
|
Notch Signaling Pathway
|
|
Signalling by NGF
|
| References |
| REF 1 | Determination of the gamma-secretase inhibitor MK-0752 in human plasma by online extraction and electrospray tandem mass spectrometry (HTLC-ESI-MS/MS). J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Sep 1;878(25):2348-52. |
|---|
