Drug General Information
Drug ID
D02EYG
Former ID
DCL000553
Drug Name
Linagliptin
Synonyms
Ondero; BI 1356; BI-1356; Ondero (TN); BI-1356-BS; (R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione
Drug Type
Small molecular drug
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Approved [541464], [551882]
Company
Boehringer Ingelheim
Structure
Download
2D MOL

3D MOL

Formula
C25H28N8O2
InChI
InChI=1S/C25H28N8O2/c1-4-5-13-32-21-22(29-24(32)31-12-8-9-17(26)14-31)30(3)25(35)33(23(21)34)15-20-27-16(2)18-10-6-7-11-19(18)28-20/h6-7,10-11,17H,8-9,12-15,26H2,1-3H3/t17-/m1/s1
InChIKey
LTXREWYXXSTFRX-QGZVFWFLSA-N
CAS Number
CAS 668270-12-0
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
A10BH05
Target and Pathway
Target(s) Dipeptidyl peptidase IV Target Info Inhibitor [537022], [550386]
KEGG Pathway Protein digestion and absorption
NetPath Pathway IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
References
Ref 541464(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6318).
Ref 551882Clinical pipeline report, company report or official report of Boehringer Ingelheim.
Ref 537022Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87.
Ref 550386Boehringer Ingelheim. Product Development Pipeline. June 2 2009.

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