Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02DTQ
|
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| Former ID |
DIB016648
|
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| Drug Name |
PF-3893787
|
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| Synonyms |
PF-03893787; PF-3826719
|
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| Drug Type |
Small molecular drug
|
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| Indication | Asthma [ICD10:J45] | Phase 1 | [1] | ||
| Company |
Pfizer Inc
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C13H22N6
|
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| Canonical SMILES |
c1(nc(cc(n1)N1C[C@@H](CC1)NC)NCC1CC1)N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Histamine H4 receptor | Target Info | Antagonist | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Reactome | Histamine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCR ligand binding | ||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6596-602. | ||||
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