Drug General Information
Drug ID
D02ADC
Former ID
DIB010216
Drug Name
SDZ-MKS-492
Synonyms
MKS-492
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Phase 1 [533607], [533957]
Company
Novartis AG
Structure
Download
2D MOL

3D MOL

Formula
C20H27N5O6
Canonical SMILES
c12c(c(=O)n(c(=O)n2C)C)n(c(n1)N[C@H](c1cc(c(cc1)OC)OC)C<br />O)CCOC
CAS Number
CAS 114606-56-3
PubChem Compound ID
Target and Pathway
Target(s) Phosphodiesterase (PDE) 3 Target Info Modulator [533607], [533957]
References
Ref 533607Effects of MKS-492 on antigen-induced bronchoconstriction and allergic reaction in guinea pigs and rats. Jpn J Pharmacol. 1993 Dec;63(4):405-13.
Ref 533957Effects of a cyclic nucleotide phosphodiesterase isoenzyme type III inhibitor, SDZ MKS 492 on airway responsiveness in beagles. Arerugi. 1993 Aug;42(8):920-5.
Ref 533607Effects of MKS-492 on antigen-induced bronchoconstriction and allergic reaction in guinea pigs and rats. Jpn J Pharmacol. 1993 Dec;63(4):405-13.
Ref 533957Effects of a cyclic nucleotide phosphodiesterase isoenzyme type III inhibitor, SDZ MKS 492 on airway responsiveness in beagles. Arerugi. 1993 Aug;42(8):920-5.

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