Drug Information

Drug General Information
Drug ID
D01ZGH
Former ID
DIB000796
Drug Name
JTK-853
Drug Type
Small molecular drug
Indication HCV infection [ICD9: 070.4, 070.5, 070.70; ICD10:B17.1, B18.2] Discontinued in Phase 1 [549089]
Company
Japan Tobacco Inc
Structure
Download
2D MOL

3D MOL
Formula
C28H23F7N6O4S2
Canonical SMILES
C1CC1C2=NC=C3C(=N2)N=C(S3)N4CCN(C(C4)C(=O)NCC5=CC(=C(C=<br />C5)OC(F)(F)F)F)S(=O)(=O)C6=CC=C(C=C6)C(F)(F)F
InChI
1S/C28H23F7N6O4S2/c29-19-11-15(1-8-21(19)45-28(33,34)35)12-37-25(42)20-14-40(26-39-24-22(46-26)13-36-23(38-24)16-2-3-16)9-10-41(20)47(43,44)18-6-4-17(5-7-18)27(30,31)32/h1,4-8,11,13,16,20H,2-3,9-10,12,14H2,(H,37,42)/t20-/m1/s1
InChIKey
JQLOVYLALGSISI-HXUWFJFHSA-N
PubChem Compound ID
57519700
PubChem Substance ID
137276664, 141540568, 163507309, 163643004, 170484516, 198945758, 224171455, 228552105, 248738281
Target and Pathway
Target(s) Hepatitis C virus NS5B polymerase Target Info Inhibitor [544247]
References
Ref 549089Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032147)
Ref 544247Preclinical Characterization of JTK-853, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase. Antimicrob Agents Chemother. 2012 August; 56(8): 4250-4256.

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