Drug General Information
Drug ID
D01UVU
Former ID
DNC014890
Drug Name
4-(3-bromopyrazolo[1,5-a]pyrimidin-6-yl)phenol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531199]
Structure
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2D MOL

3D MOL

Formula
C12H8BrN3O
Canonical SMILES
C1=CC(=CC=C1C2=CN3C(=C(C=N3)Br)N=C2)O
InChI
1S/C12H8BrN3O/c13-11-6-15-16-7-9(5-14-12(11)16)8-1-3-10(17)4-2-8/h1-7,17H
InChIKey
XBHIAJWNXVJSAA-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) AMP-activated protein kinase Target Info Inhibitor [531199]
KEGG Pathway FoxO signaling pathway
Regulation of autophagy
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Circadian rhythm
Insulin signaling pathway
Adipocytokine signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hypertrophic cardiomyopathy (HCM)
Reactome Translocation of GLUT4 to the plasma membrane
Macroautophagy
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
TP53 Regulates Metabolic Genes
WikiPathways Insulin Signaling
Energy dependent regulation of mTOR by LKB1-AMPK
JAK/STAT
BDNF signaling pathway
Leptin signaling pathway
SREBF and miR33 in cholesterol and lipid homeostasis
SREBP signalling
Signaling by Insulin receptor
TOR Signaling
AMPK Signaling
References
Ref 531199Bioorg Med Chem Lett. 2010 Nov 15;20(22):6394-9. Epub 2010 Sep 19.The rational design of a novel potent analogue of the 5'-AMP-activated protein kinase inhibitor compound C with improved selectivityand cellular activity.
Ref 531199Bioorg Med Chem Lett. 2010 Nov 15;20(22):6394-9. Epub 2010 Sep 19.The rational design of a novel potent analogue of the 5'-AMP-activated protein kinase inhibitor compound C with improved selectivityand cellular activity.

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