Drug General Information
Drug ID	D01SPJ
Former ID	DIB009765
Drug Name	Litenimod
Synonyms	Li-28; CpG oligonucleotide immunomodulator (cancer), Oligovax
Indication	Glioblastoma multiforme [ICD9: 191; ICD10:C71]		Phase 1	[551464]
Company	Oligovax SAS
Structure		Download 2D MOL
Formula	C256H322N95O129P25S25
PubChem Compound ID	56841944
Target and Pathway
Target(s)	Toll-like receptor 9	Target Info	Modulator	[543477]
KEGG Pathway	Toll-like receptor signaling pathway
	Chagas disease (American trypanosomiasis)
	African trypanosomiasis
	Malaria
	Tuberculosis
	Measles
	Herpes simplex infection
NetPath Pathway	BCR Signaling Pathway
PANTHER Pathway	Toll receptor signaling pathway
Reactome	PI3K Cascade
	Trafficking and processing of endosomal TLR
	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
	MyD88 dependent cascade initiated on endosome
WikiPathways	Toll-like receptor signaling pathway
	Toll-Like Receptors Cascades
	MyD88 dependent cascade initiated on endosome
	Trafficking and processing of endosomal TLR
	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
	Regulation of toll-like receptor signaling pathway
References
Ref 551464	Clinical pipeline report, company report or official report of Oligovax SAS.
Ref 543477	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1759).

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