Drug General Information
Drug ID
D01SLG
Former ID
DNC001056
Drug Name
Okadaic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540786]
Structure
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2D MOL

3D MOL

Formula
C44H68O13
InChI
InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49)/b10-9+/t26-,27-,28+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39-,41-,42+,43-,44-/m1/s1
InChIKey
QNDVLZJODHBUFM-WFXQOWMNSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Dual specificity protein phosphatase 1 Target Info Inhibitor [537948]
KEGG Pathway MAPK signaling pathway
Serotonergic synapse
NetPath Pathway FSH Signaling Pathway
IL2 Signaling Pathway
EGFR1 Signaling Pathway
Wnt Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
Regulation of p38-alpha and p38-beta
Direct p53 effectors
ErbB1 downstream signaling
ATF-2 transcription factor network
AP-1 transcription factor network
Reactome RAF-independent MAPK1/3 activation
Negative regulation of MAPK pathway
WikiPathways MAPK Signaling Pathway
References
Ref 540786(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5349).
Ref 537948Inhibition of protein phosphatase 1 stimulates secretion of Alzheimer amyloid precursor protein. Mol Med. 1995 Jul;1(5):535-41.

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