Drug Information

Drug General Information
Drug ID
D01OUE
Former ID
DAP001081
Drug Name
Betazole
Synonyms
Ametazole; Betazol; Betazolo; Betazolum; Betazole [INN]; Betazolo [DCIT]; Lilly 96791; Betazol [INN-Spanish]; Betazolum [INN-Latin]; 1H-Pyrazole-3-ethanamine; 2-(1H-Pyrazol-3-yl)ethanamine; 2-(1H-pyrazol-5-yl)ethanamine; 2-(3-Pyrazolyl)ethylamine; 3-(2-Aminoethyl)pyrazole; 3-(beta-aminoethyl)pyrazole
Drug Type
Small molecular drug
Indication Gastric secretory disorders [ICD9: 536.8; ICD10:K30] Approved [542134], [550718]
Therapeutic Class
Antihistamines
Company
Eli Lilly And Co
Structure
Download
2D MOL

3D MOL
Formula
C5H9N3
InChI
InChI=1S/C5H9N3/c6-3-1-5-2-4-7-8-5/h2,4H,1,3,6H2,(H,7,8)
InChIKey
JXDFEQONERDKSS-UHFFFAOYSA-N
CAS Number
CAS 105-20-4
PubChem Compound ID
7741
PubChem Substance ID
6945788, 10503079, 11112911, 11466071, 11467191, 11485822, 15066099, 17296723, 29226545, 46506808, 47943903, 47943904, 48169506, 48169507, 48415635, 49699357, 50064104, 50100538, 50759200, 57324449, 85209542, 88830371, 92741766, 103813928, 104315840, 117521710, 123083201, 125676860, 126604015, 128340252, 128340253, 131645124, 134338338, 134970986, 137006888, 137125827, 143503545, 145520280, 160963620, 162477057, 170527099, 172869629, 176243402, 178103703, 179225281, 186016280, 198968267, 223518983, 224984500, 225228099
SuperDrug ATC ID
V04CG02
SuperDrug CAS ID
cas=000105204
Target and Pathway
Target(s) Histamine H2 receptor Target Info Antagonist [537709]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 542134(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7126).
Ref 550718Drug information of Betazole, 2008. eduDrugs.
Ref 537709Effect of nizatidine and cimetidine on betazole-stimulated gastric secretion of normal subjects: comparison of effects on acid, water, and pepsin. Am J Gastroenterol. 1988 Jan;83(1):32-6.

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