Drug Information

Drug General Information
Drug ID
D01ODR
Former ID
DIB018765
Drug Name
AG 1024
Synonyms
tyrphostin AG 1024; AG-1024; AG1024
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534345]
Structure
Download
2D MOL
Formula
C14H13BrN2O
InChI
InChI=1S/C14H13BrN2O/c1-14(2,3)11-5-9(4-10(7-16)8-17)6-12(15)13(11)18/h4-6,18H,1-3H3
InChIKey
ABBADGFSRBWENF-UHFFFAOYSA-N
PubChem Compound ID
2044
PubChem Substance ID
842085, 5597980, 8151398, 14825445, 26758176, 29221227, 48334273, 57309763, 57321113, 77697430, 85787117, 99302609, 103071496, 103080977, 104299445, 117388823, 121367725, 124289246, 124659184, 126407273, 135321857, 135727819, 136348778, 136367455, 138164445, 152159567, 152344569, 162011619, 162205201, 162247721, 162631860, 163336445, 163620694, 163686008, 163688652, 164041976, 172112209, 174006534, 174530213, 178102535, 179148359, 184815471, 215785827, 223387069, 223544962, 223705282, 224799545, 235475733, 251962945, 252214682
Target and Pathway
Target(s) mRNA of Insulin-like growth factor 1 receptor Target Info Inhibitor [534345]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
Endocytosis
PI3K-Akt signaling pathway
AMPK signaling pathway
Focal adhesion
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Long-term depression
Ovarian steroidogenesis
Progesterone-mediated oocyte maturation
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
Glioma
Prostate cancer
Melanoma
PANTHER Pathway Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Insulin/IGF pathway-protein kinase B signaling cascade
Pathway Interaction Database Plasma membrane estrogen receptor signaling
SHP2 signaling
IGF1 pathway
Posttranslational regulation of adherens junction stability and dissassembly
Integrins in angiogenesis
Stabilization and expansion of the E-cadherin adherens junction
Reactome IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R
WikiPathways Senescence and Autophagy in Cancer
Insulin Signaling
Endochondral Ossification
Focal Adhesion
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Apoptosis
Signaling Pathways in Glioblastoma
TSH signaling pathway
MicroRNAs in cardiomyocyte hypertrophy
References
Ref 534345Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. Endocrinology. 1997 Apr;138(4):1427-33.
Ref 534345Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. Endocrinology. 1997 Apr;138(4):1427-33.

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