Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01NAK
|
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| Former ID |
DIB020541
|
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| Drug Name |
NMDA
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C5H9NO4
|
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| InChI |
InChI=1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1
|
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| InChIKey |
HOKKHZGPKSLGJE-GSVOUGTGSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
14414, 3153207, 7980137, 8150019, 8166769, 11111449, 11113384, 11335567, 11360806, 11364350, 11366912, 11369474, 11372520, 11374075, 11377636, 11461778, 11485256, 11489396, 11491416, 11492133, 11495270, 15120113, 15194664, 17405336, 24277987, 26612507, 26679270, 26751633, 26759138, 29290106, 46500421, 47440181, 47440182, 47588931, 47736405, 48184932, 48334418, 49872080, 50104312, 50104313, 50104314, 53777881, 56311923, 56313827, 56320631, 56320632, 57331265, 76887294, 85730947, 87573315
|
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| Target and Pathway | |||||
| Target(s) | GluN2C | Target Info | Agonist | [2] | |
| NMDA receptor subunit NR1 | Target Info | Agonist | [3] | ||
| GluN2D | Target Info | Agonist | [4] | ||
| Glutamate [NMDA] receptor subunit epsilon 2 | Target Info | Agonist | [5] | ||
| Glutamate [NMDA] receptor subunit epsilon 1 | Target Info | Agonist | [6] | ||
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| Calcium signaling pathway | |||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Circadian entrainment | |||||
| Long-term potentiation | |||||
| Glutamatergic synapse | |||||
| Alzheimer's disease | |||||
| Amyotrophic lateral sclerosis (ALS) | |||||
| Huntington's disease | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Nicotine addiction | |||||
| Alcoholismhsa04014:Ras signaling pathway | |||||
| Dopaminergic synapse | |||||
| Alcoholism | |||||
| Systemic lupus erythematosushsa04014:Ras signaling pathway | |||||
| Systemic lupus erythematosus | |||||
| PANTHER Pathway | Huntington disease | ||||
| Ionotropic glutamate receptor pathway | |||||
| Metabotropic glutamate receptor group III pathway | |||||
| Metabotropic glutamate receptor group I pathway | |||||
| Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease | |||||
| Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||||
| Pathway Interaction Database | ErbB4 signaling events | ||||
| Reelin signaling pathwayreelinpathway:Reelin signaling pathway | |||||
| Reactome | EPHB-mediated forward signaling | ||||
| Unblocking of NMDA receptor, glutamate binding and activation | |||||
| CREB phosphorylation through the activation of CaMKII | |||||
| Ras activation uopn Ca2+ infux through NMDA receptor | |||||
| RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling | |||||
| RAF/MAP kinase cascadeR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation | |||||
| RAF/MAP kinase cascade | |||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Hypothetical Network for Drug Addiction | |||||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| Spinal Cord Injury | |||||
| BDNF signaling pathway | |||||
| Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction | |||||
| BDNF signaling pathwayWP666:Hypothetical Network for Drug Addiction | |||||
| Alzheimers Disease | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4268). | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 458). | ||||
| REF 3 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 455). | ||||
| REF 4 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459). | ||||
| REF 5 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). | ||||
| REF 6 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456). | ||||
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