Drug Information

Drug General Information
Drug ID
D01MUR
Former ID
DAP000602
Drug Name
Brinzolamide
Synonyms
Azopt; Birnzolamide; Alcon brand of brinzolamide; Allphar brand of brinzolamide; Brinzolamide [USAN]; AL 4862; AL04862; BZ1; AL-4862; Azopt (TN); Brinzolamide (BRZ); Brinzolamide (JAN/USP/INN); (+)-4-ETHYLAMINO-3,4-DIHYDRO-2-(METHOXY)PROPYL-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE; (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide; (4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide; (R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide 1,1-dioxide; (R)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide; 2H-Thieno(3,2-e)-1,2-thiazine-6-sulfonamide,4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-,1,1-dioxide,R
Drug Type
Small molecular drug
Indication Open-angle glaucoma; Ocular hypertension [ICD9: 365, 365.04; ICD10:H40-H42, H40.0] Approved [536361], [541878]
Therapeutic Class
Antiglaucomic Agents
Company
Alcon Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C12H21N3O5S3
InChI
InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1
InChIKey
HCRKCZRJWPKOAR-JTQLQIEISA-N
CAS Number
CAS 138890-62-7
PubChem Compound ID
68844
PubChem Substance ID
9962, 7847718, 7886394, 8192384, 11466393, 11467513, 11486146, 11528766, 12015162, 14780300, 14878101, 26718765, 29214990, 43125358, 46394376, 46507071, 46511455, 47871124, 47871125, 48020430, 48395296, 49699073, 56463043, 57317102, 74925916, 85788886, 87325228, 92125455, 92721410, 92729740, 93166197, 103914463, 104234232, 104343207, 109692908, 117630731, 118048468, 121363126, 124800916, 126627643, 126659540, 126661718, 128041764, 134337893, 135028809, 135916574, 137005796, 143102638, 144204273, 152159683
ChEBI ID
ChEBI:3176
SuperDrug ATC ID
S01EC04
SuperDrug CAS ID
cas=138890627
Target and Pathway
Target(s) Carbonic anhydrase IV Target Info Modulator [556264]
KEGG Pathway Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 541878(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6797).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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