| Drug General Information |
| Drug ID |
D01MSM
|
| Former ID |
DNC012396
|
| Drug Name |
3-Hydroxy-7-nitro-1H-benzo[b]azepine-2,5-dione
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C10H6N2O5
|
| Canonical SMILES |
C1=CC2=C(C=C1[N+](=O)[O-])C(=CC(=O)C(=O)N2)O
|
| InChI |
1S/C10H6N2O5/c13-8-4-9(14)10(15)11-7-2-1-5(12(16)17)3-6(7)8/h1-4,13H,(H,11,14,15)
|
| InChIKey |
QIUGYFFOPLNZSP-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Glutamate [NMDA] receptor subunit epsilon 1 |
Target Info |
Inhibitor |
[1]
|
|---|
| NMDA receptor subunit NR1 |
Target Info |
Inhibitor |
[1]
|
| Glutamate [NMDA] receptor subunit epsilon 2 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Ras signaling pathway
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|
Rap1 signaling pathway
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Calcium signaling pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
|
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Circadian entrainment
|
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Long-term potentiation
|
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Glutamatergic synapse
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Dopaminergic synapse
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Alzheimer's disease
|
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Amyotrophic lateral sclerosis (ALS)
|
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Cocaine addiction
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Amphetamine addiction
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Nicotine addiction
|
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Alcoholism
|
|
Systemic lupus erythematosushsa04014:Ras signaling pathway
|
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Huntington's disease
|
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Alcoholismhsa04014:Ras signaling pathway
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Systemic lupus erythematosus
|
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PANTHER Pathway
|
Huntington disease
|
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Ionotropic glutamate receptor pathway
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Metabotropic glutamate receptor group III pathway
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Metabotropic glutamate receptor group I pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
|
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
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Pathway Interaction Database
|
Reelin signaling pathwayerbb4_pathway:ErbB4 signaling events
|
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Reelin signaling pathway
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Reactome
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Unblocking of NMDA receptor, glutamate binding and activation
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CREB phosphorylation through the activation of CaMKII
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Ras activation uopn Ca2+ infux through NMDA receptor
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RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
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RAF/MAP kinase cascade
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WikiPathways
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Hypothetical Network for Drug Addiction
|
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
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Alzheimers DiseaseWP706:SIDS Susceptibility Pathways
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Spinal Cord Injury
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BDNF signaling pathway
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Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
|
| References |
| REF 1 | J Med Chem. 1996 Nov 8;39(23):4643-53.Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. |
|---|
