Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01LPX
|
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| Former ID |
DIB016317
|
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| Drug Name |
Linotroban
|
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| Synonyms |
CL-871502; HN-11500
|
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| Drug Type |
Small molecular drug
|
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| Indication | Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] | Discontinued in Phase 2 | [1] | ||
| Company |
Nycomed AS
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C14H15NO5S2
|
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| Canonical SMILES |
S(=O)(=O)(OCC(NC(=O)OCc1ccccc1)C(=O)OCC)c1ccc(cc1)C
|
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| CAS Number |
CAS 120824-80-8
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Thromboxane A2 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Platelet activation | |||||
| Reactome | Prostanoid ligand receptors | ||||
| G alpha (q) signalling events | |||||
| G alpha (12/13) signalling events | |||||
| Thromboxane signalling through TP receptor | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Small Ligand GPCRs | |||||
| Signal amplification | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003261) | ||||
| REF 2 | Effects of the novel thromboxane (TXA2) receptor antagonist linotroban on inulin and para-aminohippuric acid clearances in the conscious male and female rat. Arzneimittelforschung. 1997 Sep;47(9):1026-30. | ||||
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