Drug Information

Drug General Information
Drug ID
D01JLO
Former ID
DIB010336
Drug Name
Tat-NR2B9c
Synonyms
NA-1; NA-1); PSD-95 inhibitor (stroke), NoNO/Arbor Vita; NMDAR NR2 domain-binding protein + HIV-1 Tat protein (Stroke), NoNO/Arbor Vita
Indication Cerebrovascular ischaemia [ICD9: 434.91; ICD10:I61-I63] Phase 3 [525512], [531828], [533640]
Company
Nono inc
Structure
Download
2D MOL
Target and Pathway
Target(s) Presynaptic density protein 95 Target Info Inhibitor [525512], [531828], [533640]
KEGG Pathway Hippo signaling pathway
Glutamatergic synapse
Huntington's disease
Cocaine addiction
PANTHER Pathway Huntington disease
Pathway Interaction Database ErbB4 signaling events
Reactome Trafficking of AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RHO GTPases activate CIT
RAF/MAP kinase cascade
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
L1CAM interactions
References
Ref 525512Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Science. 1999 Jun 11;284(5421):1845-8.
Ref 531828Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain. Nature. 2012 Feb 29;483(7388):213-7.
Ref 533640Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science. 1995 Sep 22;269(5231):1737-40.
Ref 525512Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Science. 1999 Jun 11;284(5421):1845-8.
Ref 531828Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain. Nature. 2012 Feb 29;483(7388):213-7.
Ref 533640Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science. 1995 Sep 22;269(5231):1737-40.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.