Drug Information

Drug General Information
Drug ID
D01HVS
Former ID
DIB008410
Drug Name
APD-811
Synonyms
Prostacyclin agonists (oral, pulmonary hypertension), Arena
Indication Pulmonary hypertension [ICD9: 416; ICD10:I27.0, I27.2] Phase 2 [524977]
Company
Arena Pharmaceuticals Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
OC(=O)COC[C@@H]1CC[C@@H](COC(=O)N(c2ccccc2)c3ccc(Cl)cc3<br />)CC1
InChI
1S/C23H26ClNO5/c24-19-10-12-21(13-11-19)25(20-4-2-1-3-5-20)23(28)30-15-18-8-6-17(7-9-18)14-29-16-22(26)27/h1-5,10-13,17-18H,6-9,14-16H2,(H,26,27)/t17-,18-
InChIKey
NPDKXVKJRHPDQT-IYARVYRRSA-N
Target and Pathway
Target(s) Prostacyclin receptor Target Info Agonist [544177]
KEGG Pathway Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activation
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
Endothelin Pathways
Platelet homeostasis
GPCR ligand binding
GPCR downstream signaling
References
Ref 524977ClinicalTrials.gov (NCT02279745) Long Term Safety and Efficacy of APD811 in Pulmonary Arterial Hypertension. U.S. National Institutes of Health.
Ref 544177Prostacyclin: An Inflammatory Paradox. Front Pharmacol. 2011; 2: 24.

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