Drug Information
Drug General Information | |||||
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Drug ID |
D01CUR
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Former ID |
DNC004240
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Drug Name |
3-Ethoxy-9H-beta-carboline
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [534660] | ||
Structure |
Download2D MOL |
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Formula |
C13H12N2O
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Canonical SMILES |
CCOC1=NC=C2C(=C1)C3=CC=CC=C3N2
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InChI |
1S/C13H12N2O/c1-2-16-13-7-10-9-5-3-4-6-11(9)15-12(10)8-14-13/h3-8,15H,2H2,1H3
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InChIKey |
FNNPSIGQQWCKKB-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Gamma-aminobutyric acid receptor subunit alpha-1 | Target Info | Inhibitor | [533363] | |
Gamma-aminobutyric acid receptor subunit gamma-2 | Target Info | Inhibitor | [534660] | ||
Gamma-aminobutyric-acid receptor alpha-2 subunit | Target Info | Inhibitor | [534660] | ||
Gamma-aminobutyric acid receptor | Target Info | Inhibitor | [534660] | ||
References | |||||
Ref 534660 | J Med Chem. 1998 Jul 2;41(14):2537-52.Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABAA receptors. | ||||
Ref 533363 | J Med Chem. 1988 Sep;31(9):1854-61.Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. | ||||
Ref 534660 | J Med Chem. 1998 Jul 2;41(14):2537-52.Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABAA receptors. |
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