Drug Information

Drug General Information
Drug ID
D00ZZH
Former ID
DIB002027
Drug Name
BK-218
Synonyms
7-[(3-Chloroisoxazol-5-yl)acetamido]-3-[[(1-methyl-1H-tetrazol-5-yl)thiomethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylic acid sodium salt dihydrate; 7-[2-(3-Chloroisoxazol-5-yl)acetamido]-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid sodium salt dihydrate
Drug Type
Small molecular drug
Indication Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] Terminated [544659]
Structure
Download
2D MOL

3D MOL
Formula
C15H13ClN7NaO5S2
Canonical SMILES
CN1C(=NN=N1)SCC2=C(N3C(C(C3=O)NC(=O)CC4=CC(=NO4)Cl)SC2)<br />C(=O)[O-].[Na+]
InChI
1S/C15H14ClN7O5S2.Na/c1-22-15(18-20-21-22)30-5-6-4-29-13-10(12(25)23(13)11(6)14(26)27)17-9(24)3-7-2-8(16)19-28-7;/h2,10,13H,3-5H2,1H3,(H,17,24)(H,26,27);/q;+1/p-1/t10-,13-;/m1./s1
InChIKey
XQPMNRFOIDADDS-HTMVYDOJSA-M
PubChem Compound ID
23666181
PubChem Substance ID
16715762, 33515400, 75342527, 80959992, 103849526, 117376174, 135172496
Target and Pathway
Target(s) Bacterial penicillin binding protein Target Info Inhibitor [531273]
References
Ref 544659Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000460)
Ref 531273In vitro investigation of BK-218, a new oral and parenteral cephalosporin. Antimicrob Agents Chemother. 1990 Feb;34(2):349-54.

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