TTD | Drug: D00YAZ

Drug General Information
Drug ID	D00YAZ
Former ID	DIB020791
Drug Name	R-138727
Synonyms	R 138727; R138727
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539121]
Structure		Download 2D MOL
Formula	C18H20FNO3S
InChI	InChI=1S/C18H20FNO3S/c19-14-4-2-1-3-13(14)17(18(23)11-5-6-11)20-8-7-15(24)12(10-20)9-16(21)22/h1-4,9,11,15,17,24H,5-8,10H2,(H,21,22)/b12-9-
InChIKey	ZWUQVNSJSJHFPS-XFXZXTDPSA-N
PubChem Compound ID	10405534
PubChem Substance ID	15422810, 22752846, 42235614, 74443250, 93580343, 126680908, 135650878, 139334875, 141767142, 196378240, 223665397, 226087341, 227403616, 251895071, 251895280, 252216115, 252553674, 252671941
Target and Pathway
Target(s)	P2Y purinoceptor 12	Target Info	Antagonist	[527841]
KEGG Pathway	Platelet activation
Reactome	P2Y receptors
Reactome	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Signal amplification
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 539121	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1771).
Ref 527841	Stereoselective inhibition of human platelet aggregation by R-138727, the active metabolite of CS-747 (prasugrel, LY640315), a novel P2Y12 receptor inhibitor. Thromb Haemost. 2005 Sep;94(3):593-8.

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Drug Information