Drug Information

Drug General Information
Drug ID
D00VPT
Former ID
DCL000221
Drug Name
SB222200
Synonyms
S 5192; SB 222200; SB-222200; N-(alpha-ethylbenzyl)-3-methyl-2-phenylquinoline-4-carboxamide; (S)-3-Methyl-2-phenyl-N-(1-phenylpropyl)-4-quinolinecarboxamide; 3-methyl-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide
Drug Type
Small molecular drug
Indication Schizophrenia; Schizoaffective disorders [ICD9: 295, 295.70; ICD10:F20, F25] Preclinical [525871], [539352]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C26H24N2O
InChI
InChI=1S/C26H24N2O/c1-3-22(19-12-6-4-7-13-19)28-26(29)24-18(2)25(20-14-8-5-9-15-20)27-23-17-11-10-16-21(23)24/h4-17,22H,3H2,1-2H3,(H,28,29)/t22-/m0/s1
InChIKey
MQNYRKWJSMQECI-QFIPXVFZSA-N
CAS Number
CAS 174635-69-9
PubChem Compound ID
6604009
PubChem Substance ID
11111807, 11114060, 11646426, 14927097, 17404663, 24278254, 26732637, 43223799, 46500403, 47870818, 50104836, 50104837, 53777206, 77693440, 90341726, 92303495, 103046613, 103170209, 103948293, 114637120, 121147439, 121360866, 124749447, 124800307, 124881455, 124881456, 124881457, 124881458, 124881459, 128633500, 134346203, 135262014, 135650991, 135698229, 136367791, 137010341, 143156212, 152344470, 162022854, 162248299, 163122207, 163564054, 179235919, 196370284, 204360504, 210275303, 210280952, 223490642, 225135727, 229152082
Target and Pathway
Target(s) Nigral tachykinin NK(3) receptor Target Info Antagonist [536641], [536693], [536987]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 525871Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist. J Pharmacol Exp Ther. 2000 Oct;295(1):373-81.
Ref 539352(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2131).
Ref 536641Substance P depolarizes striatal projection neurons and facilitates their glutamatergic inputs. J Physiol. 2008 Apr 15;586(8):2143-55. Epub 2008 Feb 28.
Ref 536693Neurokinin B/NK3 receptors exert feedback inhibition on L-DOPA actions in the 6-OHDA lesion rat model of Parkinson's disease. Neuropharmacology. 2008 Jun;54(7):1143-52. Epub 2008 Mar 18.
Ref 536987Evidence for mediation of nociception by injection of the NK-3 receptor agonist, senktide, into the dorsal periaqueductal gray of rats. Psychopharmacology (Berl). 2009 May;204(1):13-24. Epub 2008 Dec 18.

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