| Drug General Information |
| Drug ID |
D00VKV
|
| Former ID |
DNC003501
|
| Drug Name |
Tenocyclidine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C15H23NS
|
| Canonical SMILES |
C1CCC(CC1)(C2=CC=CS2)N3CCCCC3
|
| InChI |
1S/C15H23NS/c1-3-9-15(10-4-1,14-8-7-13-17-14)16-11-5-2-6-12-16/h7-8,13H,1-6,9-12H2
|
| InChIKey |
JUZZEWSCNBCFRL-UHFFFAOYSA-N
|
| CAS Number |
CAS 21500-98-1
|
| PubChem Compound ID |
|
| PubChem Substance ID |
5276595, 8188273, 14798602, 29216149, 43119828, 46505124, 50017186, 57314831, 77137543, 103188676, 103904012, 103917857, 104326548, 109613831, 117404002, 128331477, 134222130, 135019317, 137001269, 144205386, 160644985, 160964767, 179323264, 198948198, 226830037, 241039513, 249964299
|
| Target and Pathway |
| Target(s) |
Glutamate [NMDA] receptor subunit epsilon 1 |
Target Info |
Antagonist |
[1]
|
|---|
| Glutamate [NMDA] receptor subunit epsilon 2 |
Target Info |
Antagonist |
[1]
|
|
KEGG Pathway
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
Calcium signaling pathway
|
|
cAMP signaling pathway
|
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Neuroactive ligand-receptor interaction
|
|
Circadian entrainment
|
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Long-term potentiation
|
|
Glutamatergic synapse
|
|
Dopaminergic synapse
|
|
Alzheimer's disease
|
|
Amyotrophic lateral sclerosis (ALS)
|
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Cocaine addiction
|
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Amphetamine addiction
|
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Nicotine addiction
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Alcoholism
|
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Systemic lupus erythematosushsa04014:Ras signaling pathway
|
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Huntington's disease
|
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Systemic lupus erythematosus
|
|
PANTHER Pathway
|
Huntington disease
|
|
Ionotropic glutamate receptor pathway
|
|
Metabotropic glutamate receptor group III pathway
|
|
Metabotropic glutamate receptor group I pathway
|
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
|
|
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
|
Pathway Interaction Database
|
Reelin signaling pathwayerbb4_pathway:ErbB4 signaling events
|
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Reelin signaling pathway
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|
Reactome
|
Unblocking of NMDA receptor, glutamate binding and activation
|
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CREB phosphorylation through the activation of CaMKII
|
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Ras activation uopn Ca2+ infux through NMDA receptor
|
|
RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
|
|
RAF/MAP kinase cascade
|
|
WikiPathways
|
Hypothetical Network for Drug Addiction
|
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
|
Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
|
|
BDNF signaling pathway
|
| References |
| REF 1 | The binding of [3H]thienyl cyclohexylpiperidine ([3H]<span class="caps">TCP</span>) to the <span class="caps">NMDA</span>-phencyclidine receptor complex. Neuropharmacology. 1989 Jan;28(1):1-7. |
|---|
