Drug General Information
Drug ID	D00VFE
Drug Name	Saralasin Acetate
Synonyms	Sarenin
Drug Type	Small molecular drug
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Approved	[551871]
Company	Procter And Gamble Pharmaceuticals Inc Sub Procter And Gamble Co
Structure		Download 2D MOL
Formula	C42H65N13O10
PubChem Compound ID	36736
Target and Pathway
Target(s)	Type-1 angiotensin II receptor	Target Info	Modulator	[556264]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Renin-angiotensin system
	Renin secretion
	Pathways in cancer
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Pathway Interaction Database	Arf6 trafficking events
	Arf6 signaling events
	Angiopoietin receptor Tie2-mediated signaling
PathWhiz Pathway	Angiotensin Metabolism
	Muscle/Heart Contraction
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
WikiPathways	ACE Inhibitor Pathway
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	Allograft Rejection
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 556264	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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