Drug Information
Drug General Information | |||||
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Drug ID |
D00UTU
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Former ID |
DNC007561
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Drug Name |
7-bromoindirubin-3-acetoxime
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [1] | ||
Structure |
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Download2D MOL |
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Formula |
C18H12BrN3O3
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Canonical SMILES |
CC(=O)ONC1=C(NC2=CC=CC=C21)C3=C4C=CC=C(C4=NC3=O)Br
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InChI |
1S/C18H12BrN3O3/c1-9(23)25-22-16-10-5-2-3-8-13(10)20-17(16)14-11-6-4-7-12(19)15(11)21-18(14)24/h2-8,20,22H,1H3
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InChIKey |
GWCPNAAIJXYZLA-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Aurora protein kinase | Target Info | Inhibitor | [1] | |
KEGG Pathway | Oocyte meiosis | ||||
Reactome | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | ||||
Separation of Sister Chromatids | |||||
Resolution of Sister Chromatid Cohesion | |||||
RHO GTPases Activate Formins | |||||
WikiPathways | EGF/EGFR Signaling Pathway | ||||
JAK/STAT | |||||
Gastric Cancer Network 1 | |||||
Integrated Breast Cancer Pathway | |||||
APC/C-mediated degradation of cell cycle proteins | |||||
References | |||||
REF 1 | J Med Chem. 2007 Aug 23;50(17):4027-37. Epub 2007 Aug 1.An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. | ||||
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