Drug General Information
Drug ID	D00SOZ
Former ID	DIB001660
Drug Name	DE-117
Indication	Glaucoma [ICD9: 365; ICD10:H40-H42]		Phase 2	[524813]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Prostaglandin E2receptor, EP2 subtype	Target Info	Agonist	[551625]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
	Renin secretion
	Pathways in cancer
Reactome	Prostanoid ligand receptors
	G alpha (s) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Ovarian Infertility Genes
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 524813	ClinicalTrials.gov (NCT02179008) Multi-center Phase II Study Assessing the Safety and Efficacy of DE-117 Ophthalmic Solution in Subjects With Primary Open-angle Glaucoma or Ocular Hypertension. U.S. National Institutes of Health.
Ref 551625	Clinical pipeline report, company report or official report of Santen Pharmaceutical.

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