Drug Information

Drug General Information
Drug ID
D00RJA
Former ID
DNC001506
Drug Name
VX-148
Drug Type
Small molecular drug
Indication Psoriasis [ICD9: 696; ICD10:L40] Discontinued in Phase 2 [547204]
Structure
Download
2D MOL

3D MOL
Formula
C23H25N5O4
Canonical SMILES
CCC(CC#N)OC(=O)NC(C)C1=CC(=CC=C1)NC(=O)NC2=CC(=C(C=C2)C<br />#N)OC
InChI
1S/C23H25N5O4/c1-4-20(10-11-24)32-23(30)26-15(2)16-6-5-7-18(12-16)27-22(29)28-19-9-8-17(14-25)21(13-19)31-3/h5-9,12-13,15,20H,4,10H2,1-3H3,(H,26,30)(H2,27,28,29)/t15-,20?/m0/s1
InChIKey
PJFQWSNOXLEDDZ-OOJLDXBWSA-N
PubChem Compound ID
56603796
PubChem Substance ID
134340677, 142275745, 237427447, 243916274
Target and Pathway
Target(s) Inosine-5'-monophosphate dehydrogenase Target Info Inhibitor [535538]
References
Ref 547204Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013965)
Ref 535538Characterization of pharmacological efficacy of VX-148, a new, potent immunosuppressive inosine 5'-monophosphate dehydrogenase inhibitor. J Pharmacol Exp Ther. 2002 Sep;302(3):1272-7.

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