Drug General Information
Drug ID	D00PLM
Former ID	DNC006967
Drug Name	N-hydroxy-5-(pyridin-3-yl)thiophene-2-carboxamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528523]
Structure		Download 2D MOL 3D MOL
Formula	C10H8N2O2S
Canonical SMILES	C1=CC(=CN=C1)C2=CC=C(S2)C(=O)NO
InChI	1S/C10H8N2O2S/c13-10(12-14)9-4-3-8(15-9)7-2-1-5-11-6-7/h1-6,14H,(H,12,13)
InChIKey	VJJJKVTXSSPWSW-UHFFFAOYSA-N
PubChem Compound ID	44418106
Target and Pathway
Target(s)	Histone deacetylase 1	Target Info	Inhibitor	[528523]
KEGG Pathway	Cell cycle
	Notch signaling pathway
	Thyroid hormone signaling pathway
	Huntington's disease
	Amphetamine addiction
	Alcoholism
	Epstein-Barr virus infection
	Pathways in cancer
	Transcriptional misregulation in cancer
	Viral carcinogenesis
	MicroRNAs in cancer
	Chronic myeloid leukemia
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Wnt signaling pathway
	p53 pathway
Pathway Interaction Database	Regulation of nuclear SMAD2/3 signaling
	Notch signaling pathway
	E2F transcription factor network
	Presenilin action in Notch and Wnt signaling
	Signaling events mediated by HDAC Class I
	Regulation of Telomerase
	Glucocorticoid receptor regulatory network
	Sumoylation by RanBP2 regulates transcriptional repression
	Regulation of Androgen receptor activity
	IL3-mediated signaling events
	Validated nuclear estrogen receptor alpha network
	Retinoic acid receptors-mediated signaling
	Hedgehog signaling events mediated by Gli proteins
	Regulation of nuclear beta catenin signaling and target gene transcription
	Validated targets of C-MYC transcriptional repression
	Regulation of retinoblastoma protein
	Notch-mediated HES/HEY network
Reactome	G0 and Early G1
	p75NTR negatively regulates cell cycle via SC1
	Formation of the beta-catenin:TCF transactivating complex
	NOTCH1 Intracellular Domain Regulates Transcription
	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	HDACs deacetylate histones
	Deactivation of the beta-catenin transactivating complex
	NoRC negatively regulates rRNA expression
	RNA Polymerase I Transcription Initiation
	Factors involved in megakaryocyte development and platelet production
WikiPathways	SIDS Susceptibility Pathways
	Notch Signaling Pathway
	TGF beta Signaling Pathway
	IL-6 signaling pathway
	Apoptosis-related network due to altered Notch3 in ovarian cancer
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Notch Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Neural Crest Differentiation
	TWEAK Signaling Pathway
	Integrated Breast Cancer Pathway
	Signalling by NGF
	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
	Mitotic G1-G1/S phases
	Factors involved in megakaryocyte development and platelet production
	Cell Cycle
	Androgen receptor signaling pathway
References
Ref 528523	Bioorg Med Chem Lett. 2007 Jan 15;17(2):363-9. Epub 2006 Oct 24.Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.
Ref 528523	Bioorg Med Chem Lett. 2007 Jan 15;17(2):363-9. Epub 2006 Oct 24.Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.

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