Drug Information
Drug General Information | |||||
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Drug ID |
D00NZL
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Former ID |
DNCL002326
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Drug Name |
LY2603618
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Drug Type |
Small molecular drug
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Company |
Eli Lilly
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Structure |
Download2D MOL |
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Formula |
C18H22BrN5O3
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InChI |
InChI=1S/C18H22BrN5O3/c1-11-5-16(27-10-13-8-20-3-4-26-13)15(6-14(11)19)23-18(25)24-17-9-21-12(2)7-22-17/h5-7,9,13,20H,3-4,8,10H2,1-2H3,(H2,22,23,24,25)/t13-/m0/s1
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InChIKey |
SYYBDNPGDKKJDU-ZDUSSCGKSA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
17399809, 24481461, 36453169, 77268992, 136340188, 136349524, 136367655, 136367891, 140472988, 144116162, 152258593, 160647428, 162011919, 162038076, 162109042, 164023434, 170467345, 172232490, 174007107, 174510191, 174531422, 185969758, 198976853, 223705091, 226644713, 246865050, 249565643, 251963138, 252110175
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Target and Pathway | |||||
Target(s) | Serine/threonine-protein kinase Chk1 | Target Info | Modulator | [532505] | |
Pathway Interaction Database | Fanconi anemia pathway | ||||
p73 transcription factor network | |||||
ATR signaling pathway | |||||
Circadian rhythm pathway | |||||
p53 pathway | |||||
Reactome | Activation of ATR in response to replication stress | ||||
Processing of DNA double-strand break ends | |||||
Presynaptic phase of homologous DNA pairing and strand exchange | |||||
G2/M DNA damage checkpoint | |||||
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | |||||
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | |||||
References | |||||
Ref 522807 | ClinicalTrials.gov (NCT00988858) A Study of Advanced or Metastatic Non-small Cell Lung Cancer. U.S. National Institutes of Health. | ||||
Ref 542877 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7960). |
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