Drug Information

Drug General Information
Drug ID
D00NPP
Former ID
DAP000715
Drug Name
Zanamivir
Synonyms
GANA; GNA; Relenza; ZMR; Zanamavir; MODIFIED SIALIC ACID; Zanamivir hydrate; GG167; GR121167X; GG-167; GR-121167X; Relenza (TN); Zanamivir (USAN/INN); (2R,3R,4S)-3-acetamido-4-(diaminomethylideneamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid; 4-Guanidino-NeueAc2en; 5-(acetylamino)-4-{[amino(imino)methyl]amino}-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid; 5-Acetamido-2,6-anhydro-3,4,5-trideoxy-4-guanidino-D-glycero-D-galacto-non-2-enonic acid; ZNV
Drug Type
Small molecular drug
Indication Influenza virus [ICD10:J11.1] Approved [536361]
Therapeutic Class
Antiviral Agents
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C12H20N4O7
Canonical SMILES
CC(=O)NC1C(C=C(OC1C(C(CO)O)O)C(=O)O)N=C(N)N
InChI
1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1
InChIKey
ARAIBEBZBOPLMB-UFGQHTETSA-N
CAS Number
CAS 139110-80-8
PubChem Compound ID
60855
PubChem Substance ID
10295, 626318, 7847966, 7891225, 7980905, 8034575, 12014758, 14716772, 14801980, 14851079, 26709110, 26717829, 43118193, 46386819, 46391390, 46394328, 46508581, 48416708, 49738104, 53801134, 55161598, 57314153, 79665754, 81058936, 93166507, 104234237, 104321823, 118043618, 123109441, 126666923, 127446835, 134338003, 137003633, 138943627, 139483079, 144071866, 144203211, 144205743, 151980432, 152133958, 152258463, 160647298, 160963903, 162176829, 163981441, 164235531, 164831563, 170464662, 172089037, 175267628
ChEBI ID
ChEBI:50663
SuperDrug ATC ID
J05AH01
SuperDrug CAS ID
cas=139110808
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Neuraminidase Target Info Inhibitor [535258], [536654]
KEGG Pathway Other glycan degradation
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 535258Antiviral agents for influenza, hepatitis C and herpesvirus, enterovirus and rhinovirus infections. Med J Aust. 2001 Jul 16;175(2):112-6.
Ref 536654Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008 Apr;78(1):91-102. Epub 2008 Feb 4.

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