Drug Information

Drug General Information
Drug ID
D00KRL
Former ID
DNC008385
Drug Name
Ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529139]
Structure
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2D MOL

3D MOL
Formula
C23H20N2O2
Canonical SMILES
CCOC(=O)C1=CC=C(C=C1)C2=NN(C3=CC=CC=C32)CC4=CC=CC=C4
InChI
1S/C23H20N2O2/c1-2-27-23(26)19-14-12-18(13-15-19)22-20-10-6-7-11-21(20)25(24-22)16-17-8-4-3-5-9-17/h3-15H,2,16H2,1H3
InChIKey
LPROLPQTWKDPNU-UHFFFAOYSA-N
PubChem Compound ID
10132921
Target and Pathway
Target(s) Proteinase activated receptor 4 Target Info Inhibitor [529139]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Pathways in cancer
PANTHER Pathway Blood coagulation
Pathway Interaction Database PAR4-mediated thrombin signaling events
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Thrombin signalling through proteinase activated receptors (PARs)
GPCR ligand binding
GPCR downstream signaling
References
Ref 529139Bioorg Med Chem. 2008 Feb 1;16(3):1262-78. Epub 2007 Oct 25.Synthesis and antiplatelet activity of ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) derivatives.
Ref 529139Bioorg Med Chem. 2008 Feb 1;16(3):1262-78. Epub 2007 Oct 25.Synthesis and antiplatelet activity of ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) derivatives.

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