Drug General Information
Drug ID
D00JXV
Former ID
DIB011236
Drug Name
INCB-10820
Synonyms
PF-4178903; Dual CCR2/CCR5 antagonist (inflammation), Pfizer
Indication Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] Investigative [543887]
Company
Incyte Corp
Structure
Download
2D MOL

3D MOL

Canonical SMILES
FC(F)(c1cc(N2CCN(C(=O)[C@@]3(C(C)C)CC[C@@H](N[C@@H]4[C@<br />@H](COCC4)OC)C3)CC2)ncc1)F
Target and Pathway
Target(s) C-C chemokine receptor type 2 Target Info Antagonist [543887]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Defensins
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543887(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 59).
Ref 543887(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 59).

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